Differential selectivity of endothelium-derived relaxing factor and nitric oxide in smooth muscle
نویسندگان
چکیده
منابع مشابه
The Possible Involvement of Nitric Oxide/Endothelium Derived Relaxing Factor in Atropine-Induced Vasorelaxation
Atropine has been used to block cholinergic neurotransmission in basic research. Large doses of atropine cause vasodilation of the blood vessels in the skin. This effect is apparently unconnected with the antimuscarinic activity of atropine and seems to be due to a direct action on the blood vessels. It has been suggested that atropine blocks muscarinic receptors at low doses and it induces th...
متن کاملThe identification of nitric oxide as endothelium-derived relaxing factor.
The identification of endothelium-derived relaxing factor as nitric oxide (NO) dramatically altered the course of vascular biology, as well as other biomedical disciplines. The ubiquity of this natural product of cell metabolism and the complexity of its biochemistry provide a rich source of molecular mediators of phenotype in health and disease.
متن کاملthe possible involvement of nitric oxide/endothelium derived relaxing factor in atropine-induced vasorelaxation
atropine has been used to block cholinergic neurotransmission in basic research. large doses of atropine cause vasodilation of the blood vessels in the skin. this effect is apparently unconnected with the antimuscarinic activity of atropine and seems to be due to a direct action on the blood vessels. it has been suggested that atropine blocks muscarinic receptors at low doses and it induces the...
متن کاملAntiplatelet properties of protein S-nitrosothiols derived from nitric oxide and endothelium-derived relaxing factor.
S-nitrosothiols may serve as carriers in the mechanism of action of endothelium-derived relaxing factor (EDRF) by stabilizing the labile nitric oxide (NO) radical from inactivation by reactive species in the physiological milieu and by delivering NO to the heme activator site of guanylyl cyclase. Low-molecular-weight thiols, such as cysteine and glutathione, form S-nitrosothiol adducts with vas...
متن کاملEndothelium-Derived Relaxing Factor
The vascular effects of endothelin-1 (ET) in humans were investigated by brachial artery infusions of ET into 25 healthy volunteers. Forearm blood flow increased from a mean±SD value of 2.3± 1.5 to 2.5± 1.5 ml/min/100 ml forearm tissue (n=25, p<0.05) in response to low dose (0.5 ng/min/100 ml forearm tissue) ET infusion and decreased to 1.78±1.3 and 1.1±0.9 ml/min/100 ml forearm tissue (p<0.001...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 1987
ISSN: 0007-1188
DOI: 10.1111/j.1476-5381.1987.tb11347.x